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Cialis online

Tadalafil
Clinical data
Pronunciation ta-DAL-a-fil
Trade names Cialis, Adcirca
AHFS/Drugs.com Monograph
MedlinePlus a604008
Pregnancy
category
  • B
  • Routes of
    administration
    By mouth (tablets)
    ATC code G04BE08 (WHO)
    Legal status
    Legal status
  • ℞ (Prescription only)
  • Pharmacokinetic data
    Bioavailability Varies
    Protein binding 94%
    Metabolism Liver (predominantly CYP3A4)
    Metabolites Catechol metabolite
    Biological half-life 17.5 hours
    Excretion Feces (~61%), urine (~36%)[1]
    Identifiers
    Systematic (IUPAC) name: (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]
    pyrido[3,4-b]indole-1,4-dione
    CAS Number 171596-29-5 Y
    PubChem (CID) 110635
    IUPHAR/BPS 7299
    DrugBank DB00820 Y
    ChemSpider 99301 Y
    UNII 742SXX0ICT Y
    KEGG D02008 Y
    ChEBI CHEBI:71940 Y
    ChEMBL CHEMBL779 Y
    PDB ligand ID CIA (PDBe, RCSB PDB)
    Chemical and physical data
    Formula C22H19N3O4
    Molar mass 389.404 g/mol
    3D model (Jmol) Interactive image
    SMILES
  • O=C1N(CC(N2[C@@H]1CC3=C([C@H]2C4=CC5=C(OCO5)C=C4)NC6=C3C=CC=C6)=O)C
  • InChI
  • InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1 Y
  • Key:WOXKDUGGOYFFRN-IIBYNOLFSA-N Y
  •   (verify)

    TadalafilCialissee-AL-issAdcircaad-SUR-kuh

    Tadacip

    Side effects[edit]

    Drug interactions[edit]

    Pharmacodynamics[edit]

    This section does not cite any sources. Please help improve this section by adding citations to reliable sources. Unsourced material may be challenged and removed. (February 2011) (Learn how and when to remove this template message)

    The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5. However, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil's inhibition of PDE5 will have no effect without direct sexual stimulation of the penis. The recommended tadalafil starting dose for most men is 10 mg, taken as needed before sexual activity (but not more than once daily). The dose may be increased to 20 mg or decreased to 5 mg, per its efficacy and the man's personal tolerance of the drug. In June 2007, the European Commission approved low-dose (2.5 mg and 5 mg) Cialis to be used as single-daily ED therapy.

    On October 6, 2011, the U.S. FDA approved tadalafil to treat the signs and symptoms of benign prostatic hyperplasia (BPH). BPH is a condition in males in which the prostate gland becomes enlarged, obstructing the free flow of urine. Symptoms may include sudden urges to urinate (urgency), difficulty in starting urination (hesitancy), a weak urine stream, and more frequent urination — especially at night. The FDA has also approved tadalafil for treatment of both BPH and erectile dysfunction (ED) where the two conditions co-exist.

    Selectivity compared with other PDE5 inhibitors[edit]

    Chemistry[edit]

    History[edit]

    In 2007, Eli Lilly and Company bought the ICOS Corporation for .3 billion. As a result, Eli Lilly owned Cialis and then closed the ICOS operations, ending the joint venture and firing most of ICOS's approximately 500 employees, except for 127 employees of the ICOS biologics facility, which subsequently was bought by CMC Biopharmaceuticals A/S (CMC).

    Marketing[edit]

    Cost[edit]

    References[edit]

    External links[edit]

    • National Institutes of Health — Medlineplus
    • Material Safety Data Sheet PDF file
    • Official Cialis (tadalafil) Website
    • U.S. National Library of Medicine: Drug Information Portal — Tadalafil

    Source: https://en.wikipedia.org/wiki/Tadalafil



    Schauen Sie Video über cialis online

    How to Get Cialis Approved

    You can now buy Cialis generic with or without prescription from a doctor. You may obtain the drug from common street medical store or at via web store. There are different strength of Cialis. Men usually use the 10 or 20 mg strength of the said drug. First time users are suggested to use the lower strength type of this drug.

    Since the drug was approved by FDA last 2003, it has gain its reputation in the market as an effective anti-impotency temporary cure. The drug is not made to serve as medication for impotency but is aimed for temporary bases. Consumers were hook and admired the miracle that this drug actually gave them. There were different classifications of this drug proposed by different marketers to the male specie consumers. But there are also the generic ones that are available at web stores for cheap.

    Commonly, generic drugs are cheaper compare to the branded ones but it doesn't mean that the generic classification of this drug is less effective. Generic Cialis and those that comes from trendy brands contained same formulation and the same level of power. Brands that were highly commercialized on the Internet and is recognized by the majority are mostly the expensive ones. The generic types are 2 times cheaper and is also easy to obtain.

    There is a notion to consumers' mind that says generic drugs are less effective and not trustworthy. Thoughts that are absolutely incorrect. If you do more researches, you'd find out that the generic drugs can act the same as any other popular brands out there.

    What to expect on generic Cialis? Expect a sex drive unlike any other before. Powerful, strong and unknown sexual excitement, that's what it is going to be like when one uses this drug. The effect of the drug will be felt for as long as 36 hours. Within this time frame, one will feel the urge to make love more often. If you are an elderly, expect to get back that youthful strength and regain your 30 years old lust.

    For Cialis buyers who are not certain whether they would want to use this drug or not, you should seek your doctor's advise. If you happened to have any other serious illnesses like kidney failure or heart problem, it is best to ask your doctor first if it is okay to use the mentioned drug.

    There might be little adverse effects from this drug like dizziness and headaches. If you want to avoid these side effects, you should not take any liquor when you are taking Cialis. And remember, Cialis must be use only once per day. At some cases, men who used the drug excessively suffered from prolonged painful erection.

    You see, the only difference between branded Cialis and the generic ones is its Brand. Ask yourself, as a wise consumer, would you want to buy something expensive when you can purchase something that has the same effectiveness at a lower price? Buy Cialis generic and avoid over spending.

    Source: http://canadianpharmacyusa24h.com/



    Bilder über cialis online von Google



    Micromedex Consumer Medication Information.

    Published: November 1, 2016

    Tadalafil (By mouth)

    ta-DAL-a-fil

    Drug classes

    (About this - PubMed Health)

    Uses of This Medicine

    (PubMed Health)

    How To Use

    Drugs and Foods to Avoid

    When Not To Use

    Warnings

    Possible side effects

    Brand names include

    There may be other brand names for this medicine.

    More detailed version of this drug page

    Source: https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0012283/?report=details



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